Synthesis of N-4909 analogs. Part I. A stimulant of apolipoprotein E secretion in human hepatoma G2 cells.
نویسندگان
چکیده
Analogs of N-4909 (1), which had a stimulating activity for apolipoprotein E (apo E) secretion in Human hepatoma Hep G2 cells, were prepared and their activities examined. Cyclic analogs which had different kinds of amino acids or different number of amino acids from N-4909 (1) showed less effect on apo E secretion from Hep G2 cells. The length of acyl chain was found to be an important factor for the activity. Shorter chain reduced the activity. Linear analogs were also prepared. One of their analogs, N-5849 (17), which had six amino acids was found to have strong activity.
منابع مشابه
Solid-phase synthesis of cyclooctadepsipeptide N-4909 using a cyclization-cleavage method with oxime resin.
N-4909 (1), which has a stimulating activity on apolipoprotein E secretion in humanhepatoma Hep G2 cells, was isolated from the culture broth of Bacillus sp. No. 4691 by Hiramoto et al.l) This compound (1) was also isolated from Bacillus sp. A1238 as an inhibitor of acyl-CoA; cholesterol acyltransferase by Hasumi et al.2) This cyclooctadepsipeptide (1) and its diastereomer were synthesized for ...
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عنوان ژورنال:
- The Journal of antibiotics
دوره 53 12 شماره
صفحات -
تاریخ انتشار 2000